Capsaicin is used in several skin preparations and is used to relieve pain. It is available in the market in various forms such as ointments, creams, gels, liquids, lotions, sticks and pads under marketing names such as Capsagel, Zostrix, Arthricare for Women and Icy Hot Arthritis Treatment. A very astonishing fact is that capsaicin happens to be the active part of chili peppers. Though it is an irritant producing burning sensation on any tissue that comes in contact with it, it depletes substance P. Substance P transmits impulses of pan to the brain. It relieves pain due to diseases such as osteoarthritis, diabetes neuropathy and rheumatic arthritis. Capsaicin has not had any drug interactions till date. But this does not means that it can never have any interaction with any other drug. It is always best to confirm with your doctor if you really need to use capsaicin. Also, it is best to use this drug only in specified quantities.

Guarana is not only a dietary supplement but also an energy booster as well as it has a high concentration of caffeine.

Kola Nut, bitter brown seed that contains caffeine. Once used to make cola soft drinks, Kola Nut has been replaced by artificial flavourings in most beverages.

Yerba Matte is believed to possess cancer-fighting properties and has shown to have a relaxing effect on muscle tissues and a stimulating effect on heart tissues.

Yohimbe- Basically a tree bark, Yohimbe is rich in pharmacologically active chemicals. It is commonly found in products developed for body building and enhancing male performance. The use of Yohimbe causes serious side effects too that include renal failure, seizures and in very rare cases, even death. Individuals suffering from low blood pressure, heart disease, liver or kidney disease, and diabetes should refrain from using any kind of Yohimbe supplements. Taking larger doses of Yohimbe can cause weakness, stomach disorders, fatigue, and nervous stimulation followed by paralysis. It is therefore important to avoid self-medication. Sometimes, side effects may arise even if small amounts of this supplement are taken, especially for prolonged periods. If you are already taking drugs for treating some health condition, it is best to avoid this supplement.