Acetyl L-Carnitine is derived from methionine and lysine amino acids and this is primarily synthesized in the kidneys and liver. This is transported to various other tissues in the body. However, the highest concentration of Acetyl L Carnitine is found in the tissues that employs the fatty acids to be the primary dietary fuel mainly the cardiac and skeletal muscles. The supplement of Acetyl L Carnitine is very useful for the oxidation of fatty acid and helps in burning the unwanted body fat. The fatty acids are the main energy sources and the process called oxidation is the main to break and create it into energy. The fatty acids fail to penetrate the mitochondia membrane and Acetyl L Carnitine transports fatty acids through the mitochondia membrane allowing fats oxidation. Acetyl L Carnitine plays a vital role in the production of energy and supports the body functions that need high energy levels. This is available in many foods such as vegetables grains and meats. This is available in higher concentration in beef and lamb and the vegetables and white meats have least concentration.

Berberine , which comes from Barberry Bark Extract, is believed to regulate insulin levels.

Caffeine is the most widely used legal stimulant of the central nervous system and is also used in Lipoxene EF, with characteristics that have been described as restoration of alertness and removing from drowsiness. Coffee, Tea, many soft drinks and energy drinks as well as nutrition supplements have this ingredient, which is a psychoactive substance, a xanthine alkaloid that can act as a adenosine receptor antagonist, as well as a phosphodiesterase inhibitor. Although regular use of caffeine seems to have nootropic effects, enhancing cognitive abilities, it also is known to provide long term effects on the nervous and cardiovascular system, like in one study it was proven that people with normal to low blood pressure have the possibility of developing a heart disease significantly reduced, as well as the chance of getting the Parkinson’s disease.

Calcium, a mineral vital to the human body, Calcium is necessary for many bodily functions, such as muscle contraction, and proper heart function.

Fo-Ti is most commonly known as Chinese knotweed, with the Latin name Polygonum multiflorum. It is a Chinese herb, more accurately it is a climbing and crawling vine plant, which is able to cover quickly and rapidly everything in its path. Blooming in fall, this herb has been used in traditional Chinese medicine for ages, most prominently to rejuvenate the body. It is closely related to Japanese knotweed, which provides the antioxidant resveratrol. Chinese knotweed contains similar stilbene glycosides, which are deemed superior to the Japanese counterpart. Further properties ascribed to P. multiflorum include tonifying the kidneys, strengthening of the skeletal system, treating premature gray hair, ultraviolet protection of the skin and some laxative attributes when taken orally. Other traits seem to include normalization of estrogen profiles in women, boosting of the immune system and red blood cell formation promotion.

Green Tea Extract increases energy expenditure and affects fat oxidation, which therefore promotes weight loss by increasing the body's metabolism.

Octopamine, which is a trace amine, recently believed to be a lipotropic for fat loss. Octopamine has low oral bioavailability and is readily broken down by MAOI, as well as metabolized by the gut wall, which may mean it would not work well when taken orally, but more research is needed to prove its positive or negative effects.

Synephrine, a semi-selective sympathomimetic, is used to stimulate the adrenaline system. Also known as ‘zhi shi’, green orange or bitter orange; it is a chief, active constituent found in the fruit belonging to the plant, Citrus aurantium. Synephrine is not only similar to ephedra in its chemical composition but also serves the same benefits as caffeine or ephedrine. However, it mildly stimulates the fat metabolism without causing any of the side effects associated with ephedra based products. The best advantage of using Synephrine is that it increases the metabolic rate without affecting the hemodynamics. Thus, it is comparatively much safer than ephedra. Since Synephrine promotes weight loss and supports thermogenesis, Synephrine supplements are an ideal solution for dieters and weight watchers. The total intake should be between 2 to 10 mg. per day.